Bruno Beomonte Zobel, Riccardo Del Vescovo, Gabriele Oliva, Valentina Russo and Roberto Setola, "Assessing Bone Loss in Micro-Gravity: a Fuzzy Approach," Computational Methods and Programs in Biomedicine, vol. 108, n. 3, pag. 910-921, 2012. (doi:10.1016/j.cmpb.2012.05.001)
A prolonged stay in microgravity has various negative effects on the human body; one of these problems is a noticeable demineralization of bone tis- sues. Such effects are quite similar to those affecting osteoporotic subjects on earth, therefore it seems quite straightforward to adopt a pharmacological therapy during the stay in the space.There is therefore the need to identify a good trade-off between reduction of demineralization and side effects. In this paper an algorithm to determine the adequate combination of drugs and physical exercise is provided, with the aim to be feasibly tailored on the single astronaut during the stay in the space, by means of blood and urine analyses. Some bone metabolites have been identified, which are relevant to the phenomena while being feasible to be evaluated in the space. Moreover a model to foresee the evolution of these parameters in the space, depending on the therapy chosen, is provided. The model is derived from the experience of doctors and experts, hence it is based mainly on linguistic information; such an information is codified by means of fuzzy numbers.